Aspirin Synthesis Lab Report

Summary Determining the concentration of a liquid can be a tricky process involving complex procedures if it were not for science’s ability to test a substance’s absorbency through spectrophotometry. The experiment was carried out to discover the concentration of Red Dye #40 in several common soft drinks. The samples of the dye were diluted, and tested using a spectrophotometer. The absorbencies of these samples were then recorded, and a standard line curve with the concentration equation and R2 value was created with these results. Using the absorbencies of the dye samples, the concentrations of the soda samples were determined using the slope equation provided by the graphing software.

The purpose of this experiment was to isolate the three components of Excedrin using column chromatography. Thin layer chromatography (TLC) was used to determine when each of the components had been fully eluted from the column. If there was an overlap in fractions between two components, liquid- liquid extraction was done to separate them. The compounds were characterized via NMR instrumentation and the percent recovery for each compound was calculated to determine whether the isolation was

Water is the controlled variable in this experiment. Added Substance Amount of Apple Juice Produced (mL) Water (control

Aspirins can be used in tablets, capsules, and caplets. Aspirin has also been known to be used in a powdered form. Aspirin has the chemical formula of C9H8O4. Aspirin was one of the first common drugs that people used the most. 35,000 metric tons of Aspirin are produced annually, which is about 100 billion tablets a year.

Pages 96-98 in Chemistry 110 Lab Manual. Wilfrid Laurier University, ON, Canada. Abstract: The purpose of this experiment was to determine the level of purity by using the values for melting point and absorbance and chemically synthesizing aspirin by using phosphoric acid as a catalyst.

The Life & Death Of Super-Aspirin The life duration of super-aspirin is preventing blood clots leading to heart attacks and strokes after an angioplasty procedure and also a blood thinning agent. And the death of super-aspirin that leads to the blood thinning receptor to form more blood clots, than fewer. The life survival of angioplasty procedure is taking super-aspirin, which helps stop the forming of blood clots. As stated from WebMD “more super-aspirin protect heart better.”

Aspirin is considered a “polydrug” due to its variety of uses stretching from pain-relief to disease prevention. Salicylic acid is derived from the bark and leaves of the willow tree. Salicylic acid belongs to a group of phytochemicals which have been shown to have positive effects on human health. Salicylic acid is a phenolic compound that can be found in a variety of plants and is a crystal organic carboxylic acid. However, it is more commonly viewed as the primary metabolite and active compound of acetyl salicylic acid, which has been used as an anti-inflammatory drug by physicians for over 100 years.

To a stirred solution of acetanilide (2gm, 0.5moles) in dry acetonitrile (5ml) at 0-5⁰C, TiCl4 (2.8gm, 1.0moles) was added drop wise with stirring and the mixture was stirred at room temperature for 30 min. Then Sodium azide (0.93gm, 0.5 mol.) was added to it and the reaction mixture was heated at 80-90⁰C. After 2 hrs remaining amount of sodium azide (0.93gm, 0.5 mol.) was added to reaction mixture and heating was continued for 4-6 hrs. The reaction was monitored by TLC after 3hrs. Then the reaction mixture was cooled and poured over crushed ice and the product separated out was filtered, washed with water, dried and recrystallized from alcohol. 5-Methyl-1-phenyl-1H-tetrazole (1).

Briefly, the cartridges were preconditioned by flushing with 2 mL of methanol and 1 mL of HPLC water. Separately, 50 µL of plasma sample plus 100 µL of an 85% phosphoric acid:water mixture (1:10) and 10 µL of internal standard solution (diclofenac at 100 µg/mL) were vortex mixeding. Then, samples were loaded into the cartridge and allowed to stand for 5 min, washed with 0.6 mL of a water:methanol mixture (95:5. v/v) and then dried under vacuum. The (S)-ketoprofen was eluted with 1 mL of an acetonitrile:methanol mixture (50:50, v/v) at a flow rate of 1 mL/min. The eluate was evaporated to dryness in a water bath at 37.0 ± 0.5 ᵒC under a gentle stream of nitrogen.

Volume of ethanol (10ml) 10 ml of ethanol solution was used for each experiment (except tube 1 for 100% ethanol concentration 20ml was used) Pipette is used for accurate

Introduction In a two-week laboratory experiment my group and I used the techniques of acid-base extraction and Thin Layer Chromatography (TLC) to extract the three active compounds in Excedrin- aspirin, acetaminophen, and caffeine- and confirm the identity of our extracted crystals. The purpose of this experiment is to introduce organic chemistry lab students to the laboratory techniques of acid-base extraction and TLC. This lab also offers the opportunity to apply the previously theoretical classroom concepts of acidity, solubility, and polarity in order to utilize acid-base extraction and TLC.

Pre- lab preparation To perform this investigation, a number of the solutions were needed to be prepared in advance. The following is the preparation process - Preparing the stock solution-The stock solution of Salicylic acid needed to be prepared well in advance before the experiment began. To do so, 1.73g of Salicylic Acid was weighed using the weighing balance. After Salicylic acid was weighed, it was transferred to a standard flask of 100cm3 and, 100cm3 of pure Ethanol (C2H5OH), was poured into the standard flask that contained the Salicylic acid.

Primer: Managing NSAID-induced Ulcer Complications - Balancing Gastrointestinal and Cardiovascular Risks2006. Available from: http://www.medscape.com/viewarticle/545617_6. 5. Oscar D. Guillamondegui M, Oliver L. Gunter J, MD, John A. Bonadies M, Jay E. Coates D, Stanley J. Kurek D, Marc A. De Moya M, et al. Stress Ulcer Prophylaxis2008.

Many elements come into the determination of the solubility-product constant for a sparingly soluble salt. One of these elements is the study of spectroscopy. Spectroscopy is defined

Spectrophotometric methods are described in this paper, the simultaneous determination of paracetamol and ibuprofen using derivatives of the ratio spectra method (Yousry M., 2011), and the determination of Ibuprofen using difference spectroscopy (Hapse S.A, 2011). The objective of this work is to use these methods to establish a straight-forward, rapid and precise method in the analysis of Ibuprofen for undergraduate laboratory practical’s. The second aim of this work is to establish a method to separate pharmacologically active components in over-the-counter medication by solvent extraction. The chosen medication, Excedrin®, contains three active components, aspirin, acetaminophen and caffeine, and a binding material. One tablet contains 250mg of aspirin, 250mg of acetaminophen and 65mg of caffeine.