Pharmacokinetics Case Study

Marsha McMillen Unit 4 Pharmacology Assignment The reasons the nitroglycerin did not work, is because Mr. Smith had consumed four whisky drinks with his dinner. He took the nitro pills one hour ago and then ten minutes before calling 911. He should have taken his pill every 5 minutes, but not to exceed more than 3 pills. When taking Nitroglycerin you should not take it after consuming alcohol, and you should follow the instruction as to how to take them. His ECG was not showing like a myocardial infarction. As the paramedic I would think that the chest pain was caused by indigestion.

The purpose of this experiment was to understand the pharmacokinetics of the drug acetaminophen within the body, specifically focusing on its partition coefficient, drug protein interaction and its bioavailability through various form of administration. The bioavailability of the drug was determined to be 100% for IV because the drug is injected directly into the systemic circulation in its active form and this is also visible on Figure 4, where the initial concentration of drug is much higher than in PO and IP. For PO and IP administration, the bioavailability was determined to be 72.6% and 39.1%, respectively. This makes sense because both of these type of administration involve the first-pass effect where a portion of the drug is metabolized by peripheral organs, especially the liver in this case, and therefore the amount of active drug reaching the circulation is less. PO administration, however has a much higher content reaching the circulation than IP, because the IP route involves passing through the whole gastrointestinal tract before being absorbed in the liver while the IP route injects the drug into the

Consistently outweighing those related to natural and semisynthetic opioids, synthetic opioids, methadone, and heroin (Dal Pan, 2016). On the other hand, nonopioid analgesics or NSAID’s like Naproxen or Ibuprofen tend to be the norm for treating mild to moderate nonspecific lower back pain due to anti-inflammatory properties and analgesic properties (Adams

Pages 96-98 in Chemistry 110 Lab Manual. Wilfrid Laurier University, ON, Canada. Abstract: The purpose of this experiment was to determine the level of purity by using the values for melting point and absorbance and chemically synthesizing aspirin by using phosphoric acid as a catalyst.

Recognizing, acknowledging, and understanding medication safety is important when administering medications. Understanding which medications are high-risk ones, being familiar with the medications being given, remembering the five most important rights when administering medications, communicating clearly, developing checking habits, and reporting the medication errors will lead to safe outcomes for the residents. However, errors do occur from a lack of experience, rushing, distractions, fatigue, doing too many things at once, not double checking, poor communication, and lack of team work. It is not only the staff that commit errors, but also the work environment that contributes to the medication error. Two examples are poor reporting systems

Reflection on Medication Administration Description (Competency 3j) I have looked over my moral development regarding medicine administration and have noticed there is the need for improved and has been agreed with my mentor to write a piece of reflection to identify areas of concern Feelings One of the major concern is the pace of dispensing and the time spent used to open charts and allocate them is one of my weakness. Although I am learner I need to back up the pace of dispensing so that patient doesn 't feel my skills is dull or boring and waste of time. I Had developed that feeling of being extra careful to avoid drug error and that makes me feel slightly nervous more also being under the influence of supervision as well. Evaluation

Without caution, it can be easy for nurses to make numerous amounts of errors when performing medication administration. These errors can potentially be deadly, or cost the hospital a lot of money. It is always important for any nurse administering medicine to abide by the six rights of medication administration. When nurses are working with medications the nurse needs to be focused on the task at hand. It is ultimately up to the nurse to provide their patient with the highest standard of quality

I chose Pharmacy Tech because my life involves around medication and my family. So as I was growing up, I always helped my family which are my number 1 priority. When I was in first grade at the age of six years old, I tend to get sick a lot of times. So when I did get sick my aunt will go buy me some OTC children’s ibuprofen for my fever’s ,

As a therapist, how will you deal with a client who has disclosed that he (or she) is an exhibitionist? If a client were to disclose their being an exhibitionist I would have many concerns beyond just this presentation. One such concern would be of the risk for developing other sexually offending behaviors (Kafka & Hennen, 1999) or their already engaged deviant behaviors that have not yet been revealed such as frottage or rape (Freund,1990) or voyeurism or child molestation (Abel & and Osborn,1992). Another secondary concern would be for any nonparaphilic disorders they may have such as mood disorders, dysthymic disorder, major depression disorder, anxiety disorder, substance use disorder, or attention-deficit/hyperactivity disorder (ADHD)

Caffeine is a chemical found naturally in few plants all over the world. From these plants it is processed into its pure form and then put into other things such as soda, energy drinks, tea, and pills. Energy drinks and soda are some of the most widely marketed products in the world, even though they contain the highest concentration of caffeine outside of pure caffeine supplements. It is a stimulant that affects everyone in strange but semi predictable ways. Research has been done on this topic since the 1920’s and many different conclusions have been reached.

Pharmacology Assignment Week 4 Marty Smith is a 67-year-old male who has called 911 after experiencing chest pain and dizziness. The paramedics arrive and notice a bottle of nitroglycerin on the table. The patient states he has angina and is to take the medication as needed for chest pain. He took one pill an hour ago and a second pill 10 minutes prior to calling 911.

Whenever a consumer uses an energy drink a series of effects begin in his/her body. The organism receives an instant boost as the caffeine successfully manages to block the duties of the adenosine, a chemical located in the brain whose function is involved with sleeping. After the completion of the process caffeine forces part of the neurons in the brain to lighten up, which later on causes the body to release the hormone adrenaline. When the hormone is active it forces the liver to provide the bloodstream with additional

When interpreting concentration measurements, factors that need to be considered include the sampling time in relation to drug dose, dosage history, patient response, and the desired medicinal targets. The goal of therapeutic drug monitoring is to use suitable concentrations of difficult-to-manage medications to optimize clinical outcomes in patients in various clinical situations. Keywords: Drug monitoring, therapeutic; Pharmacokinetics Introduction Therapeutic drug monitoring is generally defined as the measurement of specific drugs at timed intervals in order to maintain a relatively constant concentration of the medication in the bloodstream. Monitored drugs tend to have a narrow therapeutic index, that is a ratio between the toxic and therapeutic doses of medications.

An organ bath experiment was conducted to investigate the effect of agonist, histamine on guinea pig ileum (GPI) and how the antagonists, mepyramine and SIPBSDrug A affect the GPI’s response (smooth muscle contractions). A GPI simulation was conducted to compare the potencies and nature of antagonists against histamine. The control Rmax and EC50 of histamine without antagonist were 16.49gms and 2.093 x 10-7M respectively. The concentration-response curves were shifted to right parallelly and EC50 increased while Rmax remained constant when mepyramine or SIPBSDrug A was added. Besides, both antagonists showed linear graphs in Schild plot, indicating that they acted as reversible competitive antagonists.

13120 19279 104781 168300 158808 248580 Mean 13839.2 18499.0 107536.7 169413.7 166367.7 242363.0 S.D. 1113.37 717.75 10429.14 2222.91 5596.72 4450.72 C.V.(%) 8.05 3.88 9.70 1.31 3.36 1.84 N 6 6 6 6 6 6 % Recovery 74.81 63.48 68.64 Overall Recovery of Baclofen from Human Plasma Mean 68.98 S.D. 5.675 % Difference 11.33 N 3 Recovery of Baclofen d4 from Human