Introduction In a two-week laboratory experiment my group and I used the techniques of acid-base extraction and Thin Layer Chromatography (TLC) to extract the three active compounds in Excedrin- aspirin, acetaminophen, and caffeine- and confirm the identity of our extracted crystals. The purpose of this experiment is to introduce organic chemistry lab students to the laboratory techniques of acid-base extraction and TLC. This lab also offers the opportunity to apply the previously theoretical classroom concepts of acidity, solubility, and polarity in order to utilize acid-base extraction and TLC. The aim of this experiment is to take an Excedrin tablet and use the varying acidities of the 3 active components to separate them using acid-base …show more content…
Solubility matters since organic compounds tend to not be soluble in aqueous solvents, but ionic salts do easily dissolve in water. And acidity matters since we can adjust the base strength to only react with one component of Excedrin at a time, allowing for the components to be isolated. By adding a 1M solution of a basic salt, like K2HPO4 or KOH, to organic compounds, we could convert the organic components of Excedrin into ionic salt that will dissolve in aqueous solvents. Next, by adding a strong acid, like HCl, the Excedrin component is protonated causing a decrease in solubility leading to the component precipitating out of the solution and crystallizing. Acid-base extraction offers a method to separate the active components of Excedrin based on acidity and what bases they will react with. Acid-base extraction also leads to recrystallization which due to the components forming lattices usually results in pure crystals that can be analyzed with TLC. Acid-base extraction is important because it offers a different way to extract the components of a mixture that does not involving boiling the solution. The lack of temperature dependence is useful for molecules whose solubility in water do not vary significantly with temperature. This extraction method is relevant to separate the components of Excedrin providing pure products without needing to use the stock-room version of the compound. Acid-base extraction is also relevant and important because it allows a student to utilize a variety of chemistry concepts including solubility of organic compounds, solubility of salts, acidification, and
This addition aids in controlling the reproducibility and retention. Separation of the mixture via RP-HPLC can be done using continuous gradient or stepwise to move out the sample components. For every separation, the ideal gradient and volume must be
Feras Kaid Chem 2415-43 TA: Rio Assessment 1 Conclusion In this lab, there were 4 different distillations that were performed each with the same end goal to separate the two different organic compounds, cyclohexane and toluene. We used the boiling points of the two compounds to separate them using the following 4 techniques: microscale simple distillation, miniscale simple distillation, miniscale fractional packed distillation, and miniscale fractional unpacked distillation. The three different miniscale distillations were used to predict the accuracy of the distillation by comparing them to one other. The most accurate of the three distillations is the miniscale fractional packed distillation because this type uses a Vigreux column instead
1) Q: Beah moves around in time as he tells his story, flashing forward and backward. What is the effect of this technique of the overall meaning of the text? Would it be more effective if he stuck to strict chronology? Why or why not?
Pages 96-98 in Chemistry 110 Lab Manual. Wilfrid Laurier University, ON, Canada. Abstract: The purpose of this experiment was to determine the level of purity by using the values for melting point and absorbance and chemically synthesizing aspirin by using phosphoric acid as a catalyst.
Unknown A is Excedrin because they both look like white powders and they were both soluble. When the universal indicator was added they both turned red, which indicted their pH level was 4.0. Then when we tested the pH with the pH strips they both showed the pH as being 3.0. After that, we added HCl or stomach acid and both drugs dissolved and were soluble. We tested the pH and it dropped to 1.0.
We were able to eliminate certain ingredients like chlorpheniramine because this ingredient was the only neutral and the properties were not similar to the unknowns. The other team identified that the unknowns included all the ingredients except for the acetylsalicylic acid. They came up with their conclusions based off during the starch test both unknowns contained starch. They had different results than our team during the acetone solubility test. Team 2 found that both unknowns were acetone soluble, but our team found only unknown B was acetone soluble.
The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.
TLC was used to identify the actual unknown product as well as other products/reactants present in the filtered solution. The procedure was conducted by placing a TLC plate in a developing chamber that is filled with a small amount of solvent. The solvent cannot be too polar because it will cause spotted compounds on the TLC plate to rise up too fast, while a very non-polar solvent will not allow the spots to move. The polarity of the spots also determines how far it moves on the plate; non-polar spots are higher than polar ones. After spots on the TLC form, the Rf values are calculated and used to analyze the similarity of the compounds.
Entering 6th grade often brings about big changes for students. With new classes, teachers, and expectations come a variety of challenges. However, with the right educational and personal strategies, sixth graders can not only survive but thrive at school. An effective approach starts by building a supportive school community including teachers and peers who will have a positive impact on academic success, and reinforces key skills such as studying techniques and time management.
25BHS suggests to read tAfï[]me (“from doing”) with 1QIsaa and LXX. Whether we follow BHS proposal or the MT reading, the meaning of the line remains the same since in poetic parallelism the preposition ! mi in v. 13a (tB'V;m)i governs the following line (v. 13b). However, the BHS proposal is a more a plausible reading because of tAfï[]me in v. 13e. 261QIsab, Theodotion, Syriac, Targum, and Vulgate read ^yc,Þp'x] (pl.) as ^c.p.x, (sg.).
LE VIET HOA – CLASS 106 HAPPINESS IS A JOURNEY, NOT A DESTINATION ≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈≈ INTRODUCTION I hold a belief that the luckiest person is not the one who has achieved many successes, but the one who always be cheerful and energetic. The question is “How can people capitalize those positive emotions?”.
Upon cooling, it was shaken until no bubbles were formed. 20 mL of each brand of soft drinks was titrated with NaOH solution. 3 drops of phenolphthalein was used as an indicator if it has already completely reacted. The acidity can then be calculated referring on the known concentration and volume of base; and the known volume of acid.
Practical I: Acid-base equilibrium & pH of solutions Aims/Objectives: 1. To determine the pH range where the indicator changes colour. 2. To identify the suitable indicators for different titrations. 3.
The topic of this research paper will cover over Ocean Acidification and the effects on marine ecosystems. Ocean acidification is the decrease in pH levels of the Earth 's oceans, due to overbearing carbon dioxide being brought by the atmosphere. The carbon dioxide is drawn by seawater, where the chemical reactions take place, which minimize the pH levels in the ocean, the carbonate levels and the important calcium carbonate which these sea creatures need. When carbon dioxide disperses in this ocean, it causes the levels of acidity to rise towards the the surface, where most shell growth in marine animals have been stopped and has created the cause of reproductive disorders in multiple fish. Part of the problem with ocean acidification is human activity.
DETERMINATION OF PERCENTAGE ETHANOL IN BEVERAGES 1. Introduction to Gas Chromatography Gas chromatography is a very powerful separation technique for compounds that are reasonably volatile. The components of a sample partitions into two phases, the 1st of these phases is a immobile bed with a great surface area, and the other is a gas phase that permeates through the immobile bed. The sample is evaporated and passed by the mobile gas phase or the carrier gas through the column. Samples separates into the stationary liquid phase, based on their solubilities at the given temperature.