2.2.6 Antibiotic resistance
Wide spread resistance to first line of antimicrobials has complicated the selection of drugs for the treatment of shigellosis. Sulphonamides were first introduced in the early 1940s and all Shigella strains were sensitive to this drug. In 1940s, tetracycline followed by chloramphenicol, were recommended for the treatment of shigellosis because sulphonamides became ineffective. Soon, resistance to these two drugs was observed and ampicillin and co-trimoxazole came to the rescue and were found to be clinically highly effective (Ross et al., 1972; Nelson et al., 1976). However, during the epidemic in 1980s in Eastern India, S. dysenteriae type 1 strains isolated were reported to be resistant to most of the antibiotics
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Hand washing with plenty of water and soap is the most important single effective preventive strategy against shigellosis. It is emphasized that hands should be washed before eating, before feeding children, after defecation and after disposal of children’s excreta. Severe dehydration is uncommon in shigellosis; the first consideration in treating any diarrheal disease is correction of abnormalities that result from isotonic dehydration, metabolic acidosis and significant potassium loss. The oral rehydration treatment developed by the World Health Organization has proven effective and safe in the treatment of acute diarrhea, provided that the patient is not vomiting or in shock from severe dehydration. In the latter case, intravenous fluid replacement is required until initial fluid and electrolyte losses are corrected. With proper hydration, shigellosis is generally a self-limiting disease, and the decision to prescribe antibiotics is predicated on the severity of disease, the age of the patient, and the likelihood of further transmission of the infection. Effective antibiotic treatment reduces the average duration of illness from approximately 5-7 days to approximately 3 days and also reduce the period of Shigella excretion after symptoms subside. Shigellosis can usually be treated with antibiotics. The antibiotics commonly used are ampicillin, trimethoprim/sulfamethoxazole (Bactrim or Spectra), nalidixic acid, ciprofloxacin and the fluroquinolone. Appropriate treatment kills the bacteria present in the gastrointestinal tract and shortens the course of the illness (Lectures in Microbiology by Kenneth Todar). Quinolones were highly effective drug for the treatment of shigellosis. WHO
This antibiotic produced a zone of inhibition of 26mm and was therefore sensitive. After a little bit more research it was concluded that K. oxytoca produces B-lactamase, therefore making it resistant to penicillin and ampicillin (MicrobeWiki, 2015). Now that testing has been done the providers know what type of medication would be best to start with. Two out of four medications could possibly be used to attack the infection. If the patient were to take Ciprofloxacin the mechanism of action would be to inhibit relaxation of DNA; inhibit DNA gyrase in
However, this is not the agent that is used to treat reactive arthritis that is caused by this bacteria. C: Metronidazole D: Naprosyn • This is the correct answer because an NSAID is the first line treatment of Reactive arthritis. In this case we are treating the reactive arthritis and not the infection that is likely etiology. E:
Shingles also has other names such as Zoster, Herpes zoster, or Zona. It is a viral infection that causes a skin rash to the injured person. It is the same virus that infects person and causes him to chickenpox disease. There are some ways to treat people with Shingles disease, which has many symptoms that can evolve and become more dangerous if
Fleming’s penicillin alone has saved an estimated 200 million lives (New World Encyclopedia Contributors 2013). Not only would antibiotics combat 50 percent of common illness threatening seamen, but also would prevent any potential bacterial infections brought on by environmental ailments like carbon dioxide poisoning, scurvy, and malnutrition. Though antibiotics are not a safeguard against any contractible sickness, they are an explicit defense against bacterial infections, which were the most common form of infection among
The morality of Healthcare acquired infections has increased tremendously whereas; both inpatient and outpatient clients have been infected during a hospital visit. These infections has weaken the sick which may lead to additional medications, or surgery, and extended hospital stay. According to (CDC 2002), healthcare acquired infections are result of unhygienic practices in medical field. This includes ambulatory surgical centers, hospice center, nursing homes and rehabilitation centers.
TREATMENT In general, people with mild cases do not benefit from antifungal medicine. Bed rest and treatment of symptoms such as cough, fever, or chest discomfort may be advised. For chronic pulmonary infections and forms of the disease that have spread to other areas of the body, antifungal medicine is prescribed. The length of drug treatment depends on the patient 's immune status and the site of infection.
Even when the symptoms are severe, the best therapy for otherwise healthy adults is often bed rest and fluids - the same approach used for colds and infections doctors carefully monitor people with valley fever. drugs- antifungals If symptoms do not improve or get worse or if they are at increased risk of complications, the doctor may prescribe an antifungal medication such as fluconazole. Antifungal drugs are also used for people with chronic or disseminated disease. In general, antifungal drugs fluconazole (Diflucan) or itraconazole (Sporanox, Onmel) are used for all but the most severe forms of the disease coccidioidomycosis.
Moreover, Penicillin, a group of antibiotics, was discovered during this time, specifically in the 1928s by Alexander Fleming (ACS, 2023). Although the first dose of penicillin was used in 1941 by Albert Alexander, it was still a life-changing discovery as it changed the lives of many - even after the period of 1918s1939s (Wood, 2010). The discovery of penicillin allowed a lot of life-threatening diseases to be treated, such as bronchitis, tonsillitis, and pneumonia. Penicillin is known to save millions of lives. Indeed, in just World War Two, the death rate because of bacterial pneumonia would go from 18% to 1%, because of the invention of penicillin.
Until 1940, doctors could not find a cure for this disease. After that year, doctors discovered a treatment for primary, secondary, and early latent syphilis. The most used antibiotic to treat this affliction is penicillin and it is extremely effective. It only requires a single intramuscular injection of penicillin to those stages, and for those who are allergic to penicillin they can use other antibiotics such as tetracycline, doxycycline and other antibiotics. Those antibiotics are less effective than penicillin.
Diagnosing smallpox can be made in several ways; by the signs and symptoms that the person presides with; by withdrawing the variola virus from the persons blood or from the lesions; and from antibodies found in the infected persons blood that reacted to the virus. Diagnosing this virus is made in specific laboratories only where there are suitable means for testing and protecting the laboratory technicians (https://www.health.ny.gov/diseases/communicable/smallpox/fact_sheet). Treatment The infected person should be isolated and admitted in a room with negative pressure, placing them under respiratory isolation and also contact isolation. Provide supportive measures.
The doctor gives her sister medication and tells them “She should only drink clean water,” (45). But how is she supposed to get access to clean water? The doctor recommends boiling the water to kill the parasites. But there is no guarantee that there is enough water to withstand the evaporation. Waterborne illnesses are essentially impossible to avoid when 59% of the population in southern Sudan does not have access to clean drinking
This led to the development and use of a penicillinase resistant beta-lactam antibiotic, including oxacillin and flucloxacillin. Combination therapy with gentamicin can also be used to treat more serious infections, but it can have a high risk of kidney
The infection death rate of the Allies vanished amid WW2 when penicillin
The STH control and elimination programme solely depends on the chemotherapy (Bergquist & Lustingman, 2010). The wide spread use of anthelminthic might increase the risk of resistance (Albonico et al., 2003; Mascarini-Serra, 2011). After preventive chemotherapy, re-infection can occur because of interruption of treatment. The aim of chemotherapy is to eliminate infection and morbidity in the definite host or decrease transmission (Bergquist & Lustingman, 2010). But, the action of vaccine would mainly to be influence transmission through targeting the parasite in definite host, which will reduce the risk of drug failure (Bergquist & Lustingman, 2010).New vaccine will reduce the dependency on benzimidazole and can overcome drug resistance (Mascarini-Serra,
The most usually utilized solutions are chloroquine (Aralen), quinine (Qualaquin), atovaquone/proguanil (Malarone), doxycycline (Vibramycin, Oracea, Adoxa, and Atridox), artemether/lumefantrine (Coartem) and mefloquin (Lariam).