Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. Quinazolinones are the versatile nitrogen containing heterocyclic compounds. Earlier it is known as benzo-1,3-diazine and was first prepared in laboratory by Gabriel in1903 and first isolated from the chinese plant aseru.1 The name quinazoline (German : Chinazolin) was first prepared by Weddige, on observing that this was isomeric with the compounds cinnoline and quinoxaline. Paal and Bush suggested the numbering of quinazoline ring system, which is currently used.2 Quinazolinones will be classified into the following five categories based on the substitution patterns of the ring system.3 • 2-substituted-4(3H)-quinazolinones • 3-substituted-4(3H)-quinazolinones …show more content…
Quinazolinone is a building block for approximately 120 naturally occurring alkaloids isolated till date from a number of families of the plant kingdom, microorganisms and animals. The first quinazolinone, i.e., 2-cyanoquinazolinone was synthesized in the late1860’s from anthranilic acid and was found to possess anti-convulsant activity. Interest in the medicinal chemistry of quinazolinone derivatives was stimulated in the early 1950’s with the elucidation of quinazolinone alkaloid i.e, 3-[ keto-(3-hydroxy-2-piperdiyl)-propyl]-4-quinazolone from an Asian plant Dichroa febrifugin, which is an ingredient of a traditional Chinese herbal remedy, effective against malaria. Methaqualone was synthesized for the first time in 1951 and it is the most well- known synthetic quinazolinone drug, famous for its sedative and hypnotic
In recent readings about Cyntoia Brown, who according to Willingham, previously was a victim of human sex trafficking, is now serving a life sentence for murder. The source reports that Brown suffered from Fetal Alcohol Syndrome, grew up in an abusive home and ran away from her adoptive parent’s house prior to becoming involved in prostitution in Nashville. She was staying with different people and using drugs and alcohol. As a runaway, she then met a 24-year-old pimp named "Cut Throat," who eventually began physically and sexually abusing her, and forced her into prostitution according to Willingham. The article states that on August 7, 2004, Brown testified she was solicited for sex by 43-year-old Johnny Mitchell Allan, who picked her up near a Sonic parking lot and drove her back to his house.
The Xalisco were so desperate at times to make sure their product was known, they would sometimes give it away for free. On women that Quinones met outside of Columbus said that she didn't have any money to put more black tar. When a driver called her to see why she hadn't bought anything in three days, she explained how she didn't have any money. Shortly after their phone call, and drive showed up at the woman's home and gave her fifty dollars worth of heroin for free (167) She told Quinones “he wanted to keep me using, and buying from him” (168). Addicts like the idea of black tar because it was a lot easier to get their hands on then pills.
The stories about St. John 's Wort date back to the first century when a naturalist named Pliny the Elder recommended its use for snake bites. Since the plant releases a red oil that resembles blood when it is squeezed too hard, it was thought to be a plant blessed by God. Early folks thought that the oil only poured out of it on the anniversary of the day that St. John the Baptist from the Bible was beheaded, which is the 29th of August. But the timing was actually just close to the date that the plant happens to reach full maturity each year. Christians also held onto the plant while saying a rhyme to keep pagans and witches away.
Chapter 6 stated that everybody must get stoned. I agree to a certain extent since it heightens the state of consciousness and it gives individuals clarity that leads to coming up with better solutions. However, not all psychedelic drugs provide a good trip, which can be scary because it can cause horrifying thoughts. Although, different types of animals seek ways to intoxicate themselves because it lets them break free from the norm, I don’t agree that drug-seeking and drug-taking are naturally normal behaviors.
During the Iron Age, millions of women and children were burned at the stake, hanged, or tortured because they were accused of being witches. Many of the accused confessed to flying during the night to have meetings with the Devil and to cast hexes on their enemies. While many confessed after severe torture, other accused “witches" sincerely believed that they had been on a magical adventure. It is now believed by historians that one of the widely used "potions" of the witches was an alkaloid, a compound with hallucinogenic properties. We may never know that there are molecules with antitumor properties, that are active against HIV, or that could be wonder drugs for schizophrenia, for Alzheimer’s or Parkinson’s disease in the tropical plants
Quilotoa’s name was derived from 2 Quechua words “Quiru” meaning tooth and “toa” meaning queen. Legends are part of Ecuador’s culture and ancestral traditions. Local legend says the King of Volcanos, Quilotoa, lived on the surface of the lagoon. His arch nemesis, Toachi, the King of the Pacific lived beneath the lagoon. King Quilotoa loathed King Toachi because he always wandered into his realm.
INTRODUCTION In our current era, sports is increasingly being incorporated in daily routines of individuals of all ages. Sports requires an enormous amount of energy. Is it possible to replenish this lost energy? Ever since the beginning of athletic competition, competitors have searched for a ‘legal’ tool that has the potential to enhance athletic abilities (speed, stamina, muscular endurance/recovery).
Racial disparity in Brazil is best explained in Abdias Nascimento article, Quilombismo: An Afro-Brazilian Political Alternative. “I believe that the Black and mulatto the Brazilian of colour must have a racial counter-ideology and a counter position in socioeconomic terms. The Brazilian of colour must strive simultaneously for a double change: socioeconomic change in the country, and change in race and colour relations.” In 1968, through these words, Afro-Brazilian scholar, artist, and politician Abdias Nascimento called attention to the potentially divergent but essentially related nature of the two main objectives of Afro-Brazilian activism: first, to effect concrete change in the distribution of social and economic power in Brazil, and second,
Quinine bark was discovered in 1820 by the French chemists Caventou & Pelletier and used as a powerful in Malaria fevers (Mayhew, 2011). During early imperialism of 16th to 18th century Europeans went to America or Australia & pushed aside natives by building European colonies. During the later phases of imperialism they started colonizing Asia & Africa instead of pushing aside the native
On Wednesday September 23rd, I attended Hispanic Heritage Month Honoring Latina, Hispanic, and Latin American Women. During this presentation the documentary “No más bebés” was played and then a discussion followed. Dr. Julia McReynolds-Pérez (UW-L Department of Sociology) and Dr. Omar Granados (UW-L Department of Modern Languages) led the discussion. The documentary focused on an investigation of the sterilization of Mexican American Women at Los Angeles County-USC Medical Center during the 1960s and 1970s.
Impotent men under no circumstances had it so good. Viagra pioneered the oral treatment for Erectile Dysfunction. And the baton, it seems, has been transferred to Cialis. In between, Levitra additionally made its presence felt. But Cialis is the future drug that has the world on its feet.
My essential oil journey began when I realized how horrible I felt all the time. I felt constantly exhausted, moody, bloated, and was prone to headaches. After going to the doctor a few times and repeatedly getting blood tests done with no answers, I didn’t know where to turn. My doctor couldn’t figure out why I was so tired all the time, even though I was sleeping up to 11 hours a night. Finally, I took matters into my own hands, and begin researching my symptoms and looking into alternative healing methods.
Turmeric, a herb that is widely known in Asian culture and cuisine is gaining popularity in the United States. This distinctively yellow-orange powder is by no means rare; if you have ever enjoyed traditional Indian curry then you have enjoyed Turmeric. You may have also seen its extract, curcumin in the form of a pill or supplement. Curcumin makes up about 3-4% of turmeric root powder by weight.
Vitamin B1 Thiamine Although Vitamin B, was one of the first vitamins ever recognised, known for thousands of years. It was not until the late nineteenth and early twentieth century that it was recognised as having a dietary role. In the Far East consumption of “polished” or refined rice often led to Vitamin B1deficiency.
Personal Essay Pharmacy is an exciting, evolving, and indispensable branch of modern day health care. I first began to consider the pharmacy profession while researching and taking career aptitude tests in my eighth grade science class. During a school career fair, I listened to a pharmacy manager promote the profession. Not long after hearing about her passion for her career, I had a strong feeling that pharmaceutics and specifically the Doctor of Pharmacy Program were the direction I wanted to take in my life. Even though several years have passed since I made this decision, I have even stronger feelings today that this is the right career path for me.